PPIP2 study

The study aims to understand if some cases of psychiatric illness are caused by immune system problems in some people.

The immune system normally controls our ability to fight infection. If the immune system goes wrong it may cause diseases called ‘autoimmune’ diseases.

This study aims to diagnose some of these immune diseases using blood tests.

Who can we include?

  • Anyone aged 18-70
  • Currently experiencing acute psychosis symptoms: current episode lasting for at least the past two weeks but no longer than two years. (Patients can have psychosis for longer than two years but are required to have a minimum six month of remission period before latest episode).

Who do we need to exclude?

  • Patients with any other neurological disorders including multiple sclerosis, epilepsy, cerebrovascular disease, hydrocephalus, traumatic brain injury, meningo-encephalitis, systemic lupus erythematosus, CNS vasculitis
  • Patients whose primary diagnosis is drug-induced psychosis (concurrent drug use is ok).

What is involved for the patients?

  • A single blood test and brief assessment performed by the research team (approx. 15mins)
  • Patients will receive a £10 voucher to compensate for their time and inconvenience
  • The local researcher will inform the care team of blood results
  • Positive cases will be referred to the SINAPPS2 trial for eligibility screening. SINAPPS2 is a clinical trial using intravenous immunotherapy to treat patients.

For further information please contact:

Megan Setterfield
Tel: 07584 384627
Email: megan.setterfield@nhs.net


Or click her to complete our online form