Current Dementia Studies

IDEAL 2 
Are you a female either aged over 92 or under 65 with Parkinson or Lewy Body Dementia?

For further information please contact:

Rachel Smith
Email: rachel.smith67@nhs.net
Tel: 07741298288

ACROYNM : IDEAL 2 

Chief Investigator  Prof Linda Claire

University / Sponsor  University of Exeter

Principal Investigator  Margaret O’Shaugnessey

What is the study about? The aim of the IDEAL-2 programme is to provide evidence about living well with dementia, service use and areas of unmet need for people with dementia. It will build on the IDEAL cohort of 1550 people with mild-to-moderate dementia and 1286 carers, interviewed initially between 2014 and 2016 and followed up 12 and 24 months later.
The central element of IDEAL-2 is three further yearly follow-ups of the IDEAL cohort. At the time of the first follow-up we will enrich the cohort with additional participants from groups that were underrepresented in the original cohort. We will link the cohort data with administrative data to obtain information about health service use. This will be supplemented by five linked studies; the programme consists of six studies in total: 
Study One: IDEAL-2 cohort, involving three further yearly follow-ups of the IDEAL cohort including new participants, and data linkage – subject to NHS HRA and Scotland A Research Ethics Committee (REC) approvals

Who can we include? We are looking to recruit 15 participants from KMPT to the enrichment cohort.  We are looking for individuals who fulfil one of the following criteria:

  1. Are aged over 92 years

  2. Are aged under 65 years

  3. Have Parkinson dementia

  4. Have Lewy Body dementia

  5. Are female

Who do we need to exclude?  Anybody who does not fulfil the above criteria

What is involved for KMPT staff?  We would be grateful if memory clinic staff could be aware of this study and raise it’s awareness.  Any members of staff with potential participants are invited to contact the research team

What is involved for the patients?  Patients, along with an identified carer will be seen at home by a researcher and if consented into the study will be assisted in completing a questionnaire.  They will then be seen one year later.

Contact Lead Assistant: Clinical Research Coordinator:

Time For Dementia
Do you have a diagnosis of dementia (e.g. AD, Vascular Dementia, Frontotemporal dementia) and have a personal consultee (family carer or friend) available?

For further information please contact:

Jamie Harper 
Email: jamie.harper@nhs.net
Tel: 07500 032847

ACROYNM : Time for Dementia

Chief Investigator  Dr Sube Banerjee

University / Sponsor  Brighton and Sussex Medical School

Principal Investigator  Dr Uwadoka

What is the study about?  Time for Dementia (TFD) is a programme to develop, deliver and evaluate an innovative educational initiative, a longitudinal clerkship (LC), which is a model of clinical education in dementia to provide continuity of learning experience through on-going longitudinal patient contact. In TFD we seek to use a longitudinal clerkship to help students to develop an understanding of the emerging challenges presented by the ageing population, multi-morbidity and long-term conditions using dementia as an exemplar condition. Dementia causes irreversible decline in global intellectual, social and physical functioning. Over 800,000 people in the UK have dementia, and improving the care of people with dementia and their family carers is a national priority. TFD has been incorporated into the curricula for healthcare students from Canterbury Christ Church University and the University of Greenwich.  Students will visit an assigned patient and family every 3-4 months for 24 months.

Who can we include? All patients interested in the TFD programme will have a diagnosis of dementia (e.g. AD, Vascular Dementia, Frontotemporal dementia) and will have a personal consultee (family carer or friend) available. 

Who do we need to exclude?  Anybody who lives alone or resides in a care home.

What is involved for KMPT staff?  We would be grateful if memory clinic staff could be aware of this study and raise it’s awareness.  Any members of staff with potential participants are invited to contact the research team

What is involved for the patients?  To be contacted and visited by the Alzheimers Society to discuss the project further.

LOAD - Late Onset Alzheimer’s Disease Research
We are inviting people who first experienced symptoms of Alzheimer’s disease after age 64 to help with this research.

For further information please contact:

Alison Welfare-Wilson 
Email: alison.welfare-wilson@nhs.net
Tel: 01622 42 7201
Mobile: 07880 294 328

Detecting susceptibility genes for late-onset Alzheimer’s disease

Chief Investigator: Prof Julie Williams

University / Sponsor: Cardiff University

Principal Investigator: Dr A Beirne

What is the study about?

Research is focused on identifying rare genetic variants of moderate to strong effect observed in the coding regions of genes and aims to compare 300,000 DNA variants from throughout the human genome, in 20,000 AD cases and 49,000 controls. Through sample collection and collaboration we will enrich our clinical samples to include 1000 individuals with early onset AD. This group are more likely to have rare genetic changes of moderate to large effect on their development of disease.

Who can we include?

Early Onset AD inclusion criteria Less than or equal to age 64 at onset (can be of any age at study entry) Meets ADRDA/NINCDS criteria for diagnosis of probable AD Willingness to provide a blood sample Caucasian

Who do we need to exclude?:

Early onset AD exclusion criteria: Current major depressive episode, psychosis (not associated with AD), acute manic or depressive episode of bipolar disorder Current diagnosis of substance abuse or substance dependence.

YOAD - Young Onset Alzheimer’s Disease Research
We are inviting people who first experienced symptoms of Alzheimer’s disease before age 65 to help with this research.

For further information please contact:

Alison Welfare-Wilson 
Email: alison.welfare-wilson@nhs.net
Tel: 01622 42 7201
Mobile: 07880 294 328

Chief Investigator: Professor Julie Williams, Cardiff University School of Medicine.

Principal Investigator: Dr Viola Fahmy, Consultant in Old Age Psychiatry and Lead Clinician for Older Adults – North Kent

What is the study about?

Very little is known about the cause of Alzheimer's disease, however it is thought to be explained by a combination of genetic, environmental and lifestyle. By studying the genes involved in Young-onset Alzheimer’s disease we hope to learn more about why people develop the disease before the age of 65. We hope that this will translate into new treatments and better methods of diagnosis in the future. 

How you can help

We are inviting people who first experienced symptoms of Alzheimer’s disease before age 65 to help with this research. Even if you are over 65 now you can still take part if you first had symptoms before age 65.

What is involved?

Helping with our research is completely confidential and involves:

  • A trained Clinical Research Nurse or Clinical Research Coordinator visiting you either at home or at a local clinic (this visit will last around 1½ hours.)
  • Answering questions about yourself and taking part in a memory test.
  • Providing a blood sample.
  • Inviting a family member or friend to help by answering some questions about your memory and general health.